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American Journal of Public Health

What the Doctor Might Do Next After learning all the details, a doctor may: Lower the dose of tirzepatide or slow down the dose increase Recommend checking blood sugar or blood pressure at home more often Advise drinking more fluids or eating smaller meals more often Change the time tirzepatide is taken Review other medicines to remove anything that may be causing low blood pressure or low blood sugar In some cases, the doctor may suggest stopping tirzepatide if the dizziness is too strong or not going away

We caution you that forward-looking statements are not guarantees of future performance and that our actual results may differ materially from those made in or suggested by the forward-looking statements contained in this communication

Expected outcomes based on trial data: Average weight loss of 24.2% at 48 weeks (phase 2) Average weight loss of 28.7% at 68 weeks (phase 3, TRIUMPH-4) 100% of participants achieved 5% or greater weight loss 93% achieved 10% or greater 83% achieved 15% or greater Moderate weight loss protocol (8mg target) For researchers who want significant weight loss but have a lower tolerance for side effects, stopping the escalation at 8mg is a validated approach