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GLP-1s were originally developed to help manage Type 2 diabetes, but they are now commonly prescribed for weight loss

AT1R expression in mesangial cells and podocytes, induced by high glucose levels, promotes intracellular expression of profibrotic and pro-inflammatory mediators, such as transforming-growth factor beta (TGF- ), vascular endothelial growth factor (VGEF), and interleukin-6 (IL-6) leading to hyperplasia and hypertrophy, mainly of the proximal tubule, together with extracellular matrix production (34)

Hormonal changes during GLP-1 therapy and hair follicle impact Beyond nutrition, the hormonal landscape shifts significantly during GLP-1 mediated weight loss