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While such a blood type mismatch is not uncommon, it can result in alloimmunization when combined with fetal-maternal bleeding, which occurs in around 5% of pregnancies and increases throughout the gestation period [172]

Weeks 12: 2 mg once weekly Weeks 34: 4 mg once weekly Weeks 58: 8 mg once weekly Week 9+: 12 mg once weekly Efficacy and safety: The reason for the slow and gradual dosing protocol The Phase 2 clinical trial of retatrutide demonstrated that participants receiving the highest dose (12 mg) achieved up to 24% weight reduction after 48 weeks

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