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Three factors are especially critical for the KLOW blend because they specifically affect GHK-Cu: protect the copper peptide from light to avoid photo-oxidation, keep the pH in the optimal range of about 5.0 to 6.5 and avoid pH extremes, and minimize freeze-thaw cycles, as these favor aggregation and oxidation

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What exists is a strong pre-clinical foundation in rodents, a biologically plausible rationale for studying similar effects in dogs, and a clinical patient population that presents with the exact disease categories the rodent literature has focused on