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Area Postrema / Nucleus Tractus Solitarius Satiety Signaling The area postrema (AP) and nucleus tractus solitarius (NTS) in the brainstem are primary sites of amylin receptor expression and represent key nodes through which amylin analogues reduce food intake

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Overall, our results suggest that the AP is responsible for the appetite-suppressing effects of GIPR agonism but that GIP receptors in the hypothalamus underlie the ability of GIPR antagonism to enhance the weight loss effects of GLP-1R and amylin receptor agonists

The intent is to inform and educate, based on research on the topic