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The published literature investigates Melanotan 2 as a non-selective agonist at melanocortin receptors (MC1R, MC3R and MC4R) in pre-clinical and in-vitro model systems
Notably, the LASSS-pretreatment displayed greater preventive effect on nitration of Y198 compared to Y250, as revealed by re-probing with anti-nitroY198 and Y250-HGF mAbs (Figure 2b, first and second rows, lanes 2 and 3
TB-500 does not have an FDA-approved dosage because it is not FDA-approved as a drug
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