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Monitor cognition and brain health : If using GLP-1 agents, baseline cognitive testing (memory, executive function) and periodic follow-up may help document whether there is slowing of decline (though in routine practice, this is limited)
In mice, specific knockout of GSDMD or NLRP3 reduces ovarian pro-inflammatory cytokines (IL-6, IL-18, TNF-), decreases caspase-1 activity, increases follicle numbers, and delays reproductive aging (Zhou C
injection of 100 nmol kg 1 MK-801 ( n = 8 mice), 100 nmol kg 1 GLP-1 ( n = 8 mice), 100 nmol kg 1 , GLP-1MK-801 ( n = 8 mice), or vehicle (isotonic saline, n = 8 mice) in DIO mice
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