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Myeloid-specific GPX4-haploinsufficient mice develop a lupus-like disease spontaneously, but complete GPX4 ablation in neutrophils results in severe neutropenia without inducing a lupus-like disease

Cancer patients may have a higher risk of deficiency due to causes of intestinal fat malabsorption (i.e., intestinal surgery, pancreatectomy, gastrectomy) or due to oncologic treatments, such as aromatase inhibitors

Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis