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Hypochloraemia (low chloride) typically accompanies sodium losses and can contribute to metabolic alkalosis, particularly with persistent vomiting
Preclinical data in rodent models showed approximately 37% greater hepatic fat reduction versus tirzepatide-equivalent dosing, a finding cited in multiple human trial design rationales as justification for the Retatrutide vs Tirzepatide superiority hypothesis in hepatic metabolic disease contexts
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