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Appetite and sleep changes Self-reported appetite shifts (in both directions) and altered sleep difficulty falling asleep, lighter sleep, or vivid dreams are described inconsistently across community sources, with no documented dose relationship

Days 1 to 7 The skin is reported to start building pigment within about 48 hours of the first dose, with visible darkening typically showing up three to seven days in

They should not be used with DPP-4 inhibitors, in type 1 diabetes, or during pregnancy

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