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316 In KRAS/LKB1-mutant NSCLC, resistance to KRAS inhibitors such as adagrasib involves adeno-to-squamous transdifferentiation (AST), driven by Np63 and characterized by KRT6A expression

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Impaired gut barrier function caused by an unhealthy diet plays a key role in disrupting the immune-metabolic homeostasis of the gut-liver axis (GLA), leading to NAFLD

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