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Pharmacology Biochemistry and Behavior, 13(6), 895900
Rapid plasma degradation and limited, variable BBB transport make systemic peripheral dosing of the parent peptide an inefficient route of exposure for any putative central target
This connection likely stems from how glutathione interacts with the brain and nervous system
While semaglutide is considered to have an overall excellent safety profile, subjects with increased risk of the previously mentioned severe side effects are advised to exercise caution
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