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MC1R is expressed on keratinocytes, fibroblasts, dendritic cells, mast cells, and other immune cells in the skin , and MT-1-mediated MC1R activation produces anti-inflammatory effects in these cell types through cAMP-mediated suppression of NF-B activation, reduction of pro-inflammatory cytokine production including TNF-alpha and IL-6, inhibition of reactive oxygen species generation, and modulation of dendritic cell maturation and antigen presentation

272 : 3095230961 Nakamura H, De Rosa S, Roederer M, Anderson MT, Dubs JG, Yodoi J, Holmgren A, Herzenberg LA and Herzenberg LA (1996) Elevation of plasma thioredoxin levels in HIV-infected individuals

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Different types of cell death usually involve similar initial signals and molecular regulators, such as GPX4, which is also involved in apoptosis and necrotic apoptosis in various injuries