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Prolonged reliance on symptom-directed pharmacotherapy should be avoided whenever possible, as dose adjustment remains the most effective strategy for improving tolerability

This phosphorylation inhibits acetyl-CoA carboxylase, which in turn lowers the concentration of malonyl-CoA

The dermoscopic features of melanoma, particularly the characteristic pattern and presence of regression structures, were evaluated based on the videodermoscopic documentation that was captured in polarised light and at 20-fold magnification

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