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Several factors can affect how long the B12 shot lasts and how your body responds: Your B12 levels : The more deficient you are, the more dramatic and long-lasting the effects may be
Gastrointestinal conditions such as pernicious anemia (autoimmune destruction of gastric parietal cells), Crohn's disease, celiac disease, and prior gastric or ileal surgery significantly impair absorption
"Relation of blood homocysteine and its nutritional determinants to age-related maculopathy in the third National Health and Nutrition Examination Survey"
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