Several HSP90 inhibitors, including 17-DMAG (alvespimycin), 17-AAG (tanespimycin), ganetespib and geldanamycin, exhibit senolytic effects across multiple senescent cell types through distinct, cell-type-specific mechanisms
Raijmakers MTM, Roelofs HMJ, Steegers EAP et al (2003) Glutathione and glutathione S-transferases A1-1 and P1-1 in seminal plasma may play a role in protecting against oxidative damage to spermatozoa
OS has also been implicated in the process of ovarian ageing and an increased incidence of aneuploidy in ageing oocytes
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