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This was suggested to be accompanied by decreased transcription of urea cycle enzymes, restoration of nitrogen balance, and possible redistribution of nitrogen stores across organs

Biochemistry 50 , 618627 (2011)

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32,33 Moreover, immune checkpoint upregulation (PD-1, CTLA-4, TIGIT, LAG-3) and suppressive signaling cascades such as PTEN lossPI3K/AKT hyperactivation exacerbate T-cell dysfunction and resistance to ICIs