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As it is known that transactivation of Met can occur via epidermal growth factor (EGF)-dependent EGF receptor (EGFR) activation or through a constitutively activated EGFR pathway 20 , we examined whether inhibition of EGF-induced phosphorylation of EGFR by the dimeric macrocycles caused the bell-shaped response mentioned above
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This is particularly important for patients experiencing cardiovascular deconditioning as a result of prolonged bed rest or severe exercise intolerance
These two elements not only strengthen these tissues but also encourage quick healing following injury
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