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inhibition of VMAT2 reduces available dopamine that can be released into the synaptic cleft, which can reduce the symptoms associated with dopamine hypersensitivity
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In summary, although the two neurons did not die of GPX4 reduction, the study focused on only one point of GPX4 and did not delve into other regulators, indicating that there are other pathways affecting the activity of POMC neurons under obesity conditions (129)
Measurement of plasma parameters Similar to the clinical data from patients with obesity [38], MC4R KO mice showed significantly increased levels of markers of liver injury, including AST, ALT, TC, and TG (Fig
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