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As a result, it is not recommended for use in this age group

Statements Data availability statement The datasets presented in this article are not readily available because of ethical and privacy restrictions

5 Exercise as a modulator of musclevasculature interactions 5.1 Exercise-induced signaling pathways improving endothelial and muscle function Exercise constitutes a robust, pleiotropic stimulus that orchestrates adaptive responses in both skeletal muscle and the vascular endothelium, thereby facilitating the restoration and preservation of the musclevasculature axis, which tends to deteriorate with advancing age

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