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A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
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Our recent results indicate that AMPK and S6K1 are functionally expressed in the VMH and LH areas, with differential activation in response to glucose fluctuations, in both in vitro models of hypothalamic organotypic slice cultures and animals in response to fasting and re-feeding, as well as in Zucker obese rats with a lower activation degree of hypothalamic AMPK in response to fasting
Extenatide was approved by the Food and Drug Administration (FDA) in 2005 to treat type 2 diabetes
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