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Such an agent will probably have a different and complementary mode of action that enables use in combination therapy, and/or be conducive to use in clinical circumstances that are less well served by existing agents, for example in obesity, atherosclerotic CVD, heart failure, chronic kidney disease, frail sarcopenia and other conditions commonly encountered among those with type 2 diabetes [1]

Response to letter regarding article, Heart failure, saxagliptin and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trial

Research has also explored its association with inflammatory modulation and recovery mechanisms following tissue stress or injury

Drop one dose level every 4 weeks (for example, from 10mg to 7.5mg to 5mg to 2.5mg)