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10.1016/j.freeradbiomed.2006.07.019 36
Overexpression of MDM2 results in decreased level and activity of p53 (Kubbutat et al, 1997) and provides an alternative to a p53 mutation in the sense that it inactivates p53
However, transient expression may necessitate repeated infusions of ex vivo -manufactured CAR-T cells or IVT-mRNA boosters, when the tumor is not cleared (159)
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