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While many PSMA-targeted ADCs have entered the clinical pipelineincluding SHR-4394, which carries an undisclosed payload and is currently recruiting patients for its first phase I clinical trial (NCT06783829)many have failed to advance beyond phase I/II clinical trials due to modest PSA response rates, inadequate survival benefit, and significant toxicity 80,81

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doi: 10.1016/j.rbmo.2016.10.008 208 AgarwalARoychoudhurySBjugstadKBChoC-L