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(B) Semaglutide, as a GLP-1 analog, can directly act on fat cells, increase the expression of thermogenic genes for browning phenotype maintenance, improve the expression of uncoupling protein 1 (UCP1), mitochondrial biosynthesis, and thermogenic marker, or promote fatty browning through nitric oxide synthase (NOS), neuropeptides (NPs), sirtuin 1 (STRT1), signal transducer and activator of transcription 3 (STAT3), and bone morphogenetic protein 4 (BMP4) signaling
Reactive oxygen species, cellular redox systems, and apoptosis
Their tendons heal differently
On the other hand we see adults being very physically active, being taller because of growth hormone treatment during childhood , and with a normal weight they can have a daily calorie need sometimes above 2,000 kcal
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