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Treatment with hederagenin in lung cancer cells, leads to a strong upregulation of the CHAC1 gene even though basal CHAC1 expression is significantly lower than in normal tissues (Lu et al., 2024)

Conclusion The connection between L-carnitine and vitamin C is rooted in fundamental biology

In MCAD patients, triptans, e.g., sumatriptan (Imitrex), should be used cautiously, since they may increase the number of mast cells and they may aggravate MCAD-related headache/migraines

People who are heterozygous for CBS deficiency (between 1 in 70 to 1 in 200 in the general population) have normal homocysteine levels in 30% to 50% of cases