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Nicholls proposes a noninferiority margin of approximately 1.05, derived from a Bayesian meta-analysis of six GLP-1 CV outcomes trials

This mechanism addresses a common frustration during cutting phases where metabolic rate tends to decrease as the body adapts to reduced caloric intake

(Source: ScienceDaily, 2025) Semaglutide Delivers Major Weight Loss in Adults Over 65 A 2026 study presented at the European Association for the Study of Obesity found that older adults (65+) taking once-weekly semaglutide experienced substantial weight loss and improvements in multiple health measures with results similar to those seen in the broader STEP trial population

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