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Studies have examined its effects on meal patterns, food reward behavior, and CNS amylin receptor signaling in animal models contributing to understanding of the neurobiology of appetite regulation beyond GLP-1 pathway mechanisms
Toward a wiring diagram understanding of appetite control
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For context on how these results compare with single-agonist options, semaglutide (Wegovy) achieved 14.9% mean weight loss at 68 weeks in the STEP 1 trial, and retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, showed up to 24.2% weight loss in Phase 2
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