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these effects are impaired in insulin-resistant states Insulin resistance affects many aspects of kidney function, including renal haemodynamics, podocyte viability and tubular function The action of insulin on renal sodium handling is preserved in insulin resistance and contributes to sodium retention and arterial hypertension Renal and vascular insulin resistance can be improved through an integrated approach including lifestyle interventions and pharmacological agents Abstract Insulin resistance is a systemic disorder that affects many organs and insulin-regulated pathways

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However, those with thyroid conditions should exercise caution, L-carnitine may suppress the peripheral action of thyroid hormone