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Interestingly, the neurological dysfunction related to the inhibition of GABAergic neuron maturation in male double-knockout Scly / / Selenop / mice could be prevented by prepubescent castration (Pitts et al., 2015)

doi: 10.1016/j.neuropharm.2018.02.012 113

While this supports immune cell activation and enhances pathogen clearance, excessive activation may contribute to tissue injury and immunosuppression (52)