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Compared to placebo, mean mGFR reduction during empagliflozin administration was 7.2 9.5 mL/min, on losartan it was 7.5 15.9 mL/min, and on combination treatment it was 10.9 18.0 mL/min (2A)

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Moreover, metformin treatment prevented the degradation of cartilaginous proteoglycans and collagen, reduced cartilage erosion, and caused lower OARSI scores compared with the OA model group (Fig

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