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Imagine the world of GLP-1 receptor agonists as a bustling comedy club filled with hilarious mechanisms of action that keep our bodies laughing all the way to better health (and a smaller waistline)
ludwiggi protects against DSS-induced colitis by enhancing the choline/7nAChR-mediated dendritic cell immune tolerance, leading to increased Foxp3 + Treg differentiation ( + dendritic cells from Enterobacter ludwiggi -treated mice exhibited higher expression of tolerogenic markers Tgfb1, Tgfb2, Aldh1a2 , and Pdl1 , and co-culture with nave CD4 + T cells enhances Treg conversion ( Enterobacter ludwiggi exhibited reduced colitis severity and expanded Treg populations in the mesenteric lymph nodes and spleen, highlighting cholines role in shaping gut-immune interactions
Chen, J
2022;15:1430 Lewis AL, McEntee N, Holland J, Patel A
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