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261,262 Usually, mitochondrial dysfunction impairs NAD regeneration from NADH
By restoring intracellular levels of NAD and ATP, NAM facilitates energy-dependent repair mechanisms, including nucleotide excision repair and PARP-1mediated repair of UV-induced DNA damage, such as cyclobutane pyrimidine dimers (CPDs) and 8-oxoG 185
A meta-analysis of this study showed that the improvement in ALT was more frequent in patients who received vitamin E versus placebo (48% vs
Microvasc Res
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