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chronic fatigue syndrome : Chronic fatigue syndrome is a disorder characterized by symptoms such as intense tiredness, headache, sleep disorders, muscle aches, memory problems

Beyond defining a mitochondrial mechanism for fuel switching, this work provides a conceptual landscape for future investigation of metabolic adaptation across diverse physiological contexts, including exercise, distinct fasting paradigms, and hormone-driven metabolic regulation, and offers new insight into the determinants of responsiveness to GLP1R agonist-based anti-obesity therapies

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While uncomfortable, increased cold sensitivity is generally a physiological adaptation to weight loss rather than a concerning adverse reaction