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Some short-term studies in healthy older adults have been done with GHRH analogs like sermorelin or other secretagogues, and while they sometimes show increases in lean mass or decreases in fat mass, the improvements are modest and can be accompanied by side effects (e.g

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Published studies underscore a common thread of weight regain after stopping GLP-1 medications, highlighting the need for nutritional products and lasting healthy, active lifestyle habits necessary for patients to retain their results over time

PMCID: PMC4969472