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Although there were no significant subgroup interactions in the meta-analysis, there was a numerically lower risk of MACE in subjects with a history of CVD (14%, hazard ratio 0.86) vs those without such a history (6%, hazard ratio 0.94) [36]
This is known as treatment compliance
Lifestyle Interventions: Diet, exercise, and behavioral changes remain foundational for diabetes and obesity management
Besides, the crude AF/Aflutter counts were small (13 events in each arm), raising concerns about instability of estimates, and confidence intervals appear narrow
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