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Acute cardiotoxicity may emerge as acute and usually reversible heart failure and/or acute arrhythmogenicity which usually manifests as premature ventricular beats observed after 10 min to 24 h following infusion of DOX ( Regarding chronic anthracyclines cardiotoxicity, a large study from the year 2003 revealed that 5%, 16%, and 26% of patients experienced DOX-related heart failure at cumulative doses of 400, 500, and 550 mg/m 2 respectively

This epigenetic modification activates GCLC transcription, enhances glutathione synthesis, and protects against lipid peroxidation and ferroptosis, thereby driving chemoresistance in colorectal CSCs