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Discard your vial immediately if you notice: Cloudiness (Turbidity): A primary sign of bacterial contamination or chemical change
A preliminary clinical study with ALS patients demonstrated an improvement in their muscle electrical activity after two weeks of ultra-high-doses of B12 injections into the muscle
So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets
More importantly, the freezing and thawing process can affect the homogeneity of the solution
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