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One important note up front, because it shapes everything else: retatrutide is still being studied
In addition to reduction in A1C and body weight, the semaglutide 2.0 mg arm of the trial saw a greater proportion of patients achieve an A1C less than 7% (67.6% vs 57.5% [OR, 1.60
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Singh highlighted two 2025 studies: one found GLP-1 use was associated with a lower incidence of progression to advanced AMD, including neovascular AMD and geographic atrophy, while another reported an increased risk of neovascular AMD among GLP-1 users
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