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The consequence is that we cannot confidently answer basic clinical questions: What is the maximum tolerated dose in humans
They typically appear on the colon and rectum
Such approach could enhance therapeutic effectivity in cancers where iron overload accelerates oxidative stress
van den Dobbelsteen et al., 1996) and with the subsequent conflicting notion that chemical depletion of GSH was not, however, sufficient to induce the apoptotic process (Ghibelli et al., 1999
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