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In a 2-year carcinogenicity study in Sprague Dawley rats, subcutaneous doses of 0.0025, 0.01, 0.025 and 0.1 mg/kg/day were administered (below quantification, 0.4-, 1-, and 6-fold the exposure at the MRHD)
83 Concurrently, drug-resistant tumor cells upregulate Fabp7 and suppress Lpcat3 via altered H3K27ac/H3K9ac marks, leading to ferroptosis resistance, enhanced FAO, and disrupted circadian signaling in T cells, all of which contribute to immune evasion and therapy failure
Irritation and swelling at the injection site3
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