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Last Updated: July 30, 2026 Introduction to Blood Coagulation The ability of the body to control the flow of blood following vascular injury is paramount to continued survival

Mast cell activation may facilitate the entry of pathogenic antibodies into the CNS by disrupting the blood-brain barrier and attracting additional immune cells into neural tissue

The following are known triggers of mast cell degranulation (in addition to IgG activation via pathogen or allergen):[ref] Acetylcholine Complement fragments (C3, C4, C5) Various drugs, environmental toxins (MRGPRX2 receptor, details below) Peptides (including endorphin, leptin, PTH, and more) Physical conditions (cold, heat, pressure, stress, and vibration)