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This anti-inflammatory mechanism is why GLP-1 medications are being explored for conditions far beyond diabetes and weight loss
Because of this, the ability to make progress during exercise lowers and may need to be put on hold altogether
The prescription of certain VGSC-inhibiting drugs already in clinical use, such as antiepileptic drugs and antiarrhythmic agents, has been associated with reduced cancer incidence and improved survival in retrospective studies (329, 330)
Age is another major risk factor: HF has been reported to affect around 1%2% of all adults ( The pathophysiology of HF has been extensively reviewed by others ( As mentioned earlier, HF is traditionally considered as three main phenotypes: HFrEF, HFmrEF and HFpEF ( Currently available pharmacotherapeutics options in HF mostly remain focused on HFrEF, where treatments strategies aim at relief of symptoms, improving quality of life, and prolonging the life of the affected individual ( GLP-1 receptor agonism in heart failure Clinical evidence Only a few clinical investigations studying the effects of GLP-1 RAs specifically in HF (all in HFrEF) have been reported as briefly discussed below
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