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394 OXPHOS function measured in blood cells is emerging as a potential biomarker, with an estimated sensitivity of 68.3%, directly reflecting OXPHOS defects
Khunti K, Nikolajsen A, Thorsted BL, Andersen M, Davies MJ, Paul SK
References Lehmann EW, Torekov SS
Key research implications include: Glycemic durability: Long-term HbA1c reductions without compensatory hyperglycemia Cardiovascular signaling: Improved lipid profiles and blood pressure suggest systemic metabolic benefits High-risk subgroups: Differential responses in high-BMI and insulin-resistant populations provide insight into personalized metabolic research strategies Collectively, Phase 3 data position retatrutide as a critical tool for exploring glucagon signaling beyond its classical role in glucose regulation
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