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Further, it caused an increase in the activation of the Akt/GSK-3 pathway, indicating that IGF-1 could be a potential therapy for diabetic cardiomyocytes [9]

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In Se deficiency, GPx activity decreases, degradation of H2O2 is reduced, thyroid cells are less resistant to oxidative stress, apoptosis and cell death occur ( 3 Se deficiency is one of the risk factors for many thyroid diseases 3.1 Se and Graves disease The main clinical manifestation of Graves disease (GD), also known as toxic diffuse goiter, is thyrotoxicosis caused by excessive production of thyroid hormones

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The yeast cell biomass was obtained by centrifugation of culture medium (3000 g , 10 min, + 4 C, Centrifuge 5804R Eppendorf, Germany) containing potato wastewater enriched with glycerol

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