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Qsymia (phentermine-topiramate) is not licensed for use in the UK by the MHRA Wegovy (semaglutide) is a GLP-1 receptor agonist licensed in the UK and should not be combined with other weight management products according to its Summary of Product Characteristics No clinical trials have investigated the safety or efficacy of combining these two medications Potential risks include cardiovascular effects, amplified gastrointestinal side effects, and central nervous system disturbances UK guidance from NICE recommends single-agent pharmacotherapy optimised within specialist weight management services Sequential therapy or bariatric surgery referral are evidence-based alternatives for patients not responding to single-agent treatment Table of Contents Understanding Qsymia and Wegovy: Different Mechanisms for Weight Loss Can You Take Qsymia and Wegovy Together