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The nausea and appetite suppression it causes follow directly from the locations of those receptors (Wilding et al., NEJM 2021)

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Hashimoto's patients have higher rates of pernicious anemia (B12 deficiency) due to autoimmune gastritis co-occurrence

This is clinically favorable (improved drug metabolism) but creates a transient period of unpredictable pharmacokinetics during active fibrosis regression

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