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Thoughtful monitoring after discontinuation is required to identify any rebound or shifts in health

Unreconstituted lyophilized tirzepatide has a dramatically longer shelf life (up to 24 months) compared to reconstituted liquid (28 to 30 days)

C3/C2 = propionyl-CoA carboxylase (elevated in propionic/methylmalonic acidemia)

The study had two objectives: to demonstrate PF3944 could achieve continued weight loss when switching from weekly to monthly subcutaneous injections and maintain its efficacy while reducing the dosing frequency four-fold and to demonstrate PF3944 could switch to a four-fold equivalent monthly dose while maintaining a well-tolerated and favorable safety profile