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Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014

Mounjaro, containing tirzepatide, works similarly to semaglutide but targets both GLP-1 and GIP receptors, potentially enhancing its effects on blood sugar and weight loss

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Concierge-medicine write-ups argue that starting both peptides together lets BPC-157 act on the early inflammatory milieu while TB-500 accumulates in tissue for the longer migratory phase, avoiding a gap if dosing were staggered [2]