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More recent work linked long-term NS work ( 10 years) to significant hypomethylation in 85 CpG sites, including loci in ZFHX3, a gene involved in circadian rhythm regulation and tumor suppression, and ATXN7, associated with transcriptional control and cancer susceptibility 231
We further assessed the consequence of increased tonic GABA inhibition by evaluating the spike probability of layer V neurons in the IL cortex by measuring the spike probability upon electrical stimulation of the layer II/III circuit
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